Founded in 1974, Luisa Strina has helped foster the careers of a new generation of conceptual artists from Brazil, including Antonio Dias, Waltercio Caldas, Cildo Meireles and Tunga. In 1992, the gallery was the first from Latin American to join Art Basel.

Luisa Strina started to work with emerging Brazilian artists, such as Alexandre da Cunha, Fernanda Gomes, Marepe, amongst others. Over the 2000s, the artist roster was expanded to incorporate a new group of Latin American artists — Carlos Garaicoa, Jorge Macchi, Juan Araujo and Pedro Reyes — and leading female contemporary artists, such as Laura Lima, Leonor Antunes and Renata Lucas. In the last decade, the gallery has consolidated its trajectory with the representation of influential names including Alfredo Jaar and Anna Maria Maiolino as well as younger artists, such as Bruno Baptistelli and Panmela Castro.